These access methods are ideal for all well written applications that predominantly use relative URLs. JavaScript may also behave better with these access methods than the Translated Web Access.
The following applications are recommended for Custom Port Mapped or Custom FQDN Mapped Web Access over Translated Web Access:
Share Point2010, SharePoint 2013, SharePoint 2016
Outlook Web Access 2013, Outlook Web Access 2016
Domino Web Access
Complex web applications (JavaScript/other advanced web technologies)